For centuries, this herb has been used in fighting hangovers (9). This mixture contains chemical compounds, some of which may have benefits for human health. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. But it may be a helpful complementary treatment to try if a healthcare professional approves it. Agency for Healthcare Research and Quality (US); 2000. Some people claim it can help to treat: cirrhosis. Milk thistle may help to stop the spread of certain types of cancer. The following two tabs change content below. Some people also call it Mary thistle and holy thistle. The study looked specifically at bone loss caused by a deficiency in estrogen among rats that had their ovaries removed. Regardless, interactions are still possible. JAMA. Wu J-W, Lin L-C, Tsai T-H. Drugdrug interactions of silymarin on the perspective of pharmacokinetics. The survey revealed anecdotal evidence of the improved quality of life among those who took milk thistle, despite having no measurable improvements in hepatitis symptoms like liver inflammation. Milk thistle is native to the Mediterranean region. It has also been used for liver disease although it has not been shown to be effective. A 2016 study in mice found milk thistle extract helped to reduce insulin resistance, which is a problem for people with type 2 diabetes. A.D.A.M. Potensi Tinggi Setiap kapsul mengandung 1.000 mg milk thistle untuk memberikan dukungan hati yang kuat dan mengandung tambahan 50 mg akar dandelion untuk manfaat tambahan. 2005;100(11):2583-91. doi:10.1111/j.1572-0241.2005.00262.x. Effect of continuous silymarin administration on oral talinolol pharmacokinetics in healthy volunteers. The most common use of milk thistle is for liver problems. Milk thistle is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. Silymarin, a Promising Pharmacological Agent for Treatment of Diseases, Iranian University of Medical Sciences, US National Library of Medicine, National Institutes of Health. Does milk thistle cause any side effects? Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Milk thistle (Silybum marianum) is a herb loaded with antioxidants and is known for its anti-inflammatory properties. Milk thistle ( Silybum marianum L. More studies with human participants could allow scientists to say with certainty that milk thistle supports a persons immune system. So, consult a doctor to understand about its long term usage. However, consult your doctor for the best advice. 2016;2016:5147468. doi:10.1155/2016/5147468. Selected from data included with permission and copyrighted by First Databank, Inc. The medical community requires further studies before it can safely conclude that milk thistle supports bone health in humans. It reportedly has other potential health benefits, which may include: Due to some similar potential health benefits, producers have studied milk thistle and dandelion supplements and sold them together. Medical News Today only shows you brands and products that we stand behind. Otherwise, call a poison control center right away. Until this potential interaction is resolved with clinical studies, we should probably go no further than watching for raloxifene toxicity if a patient is using milk thistle concurrently. Consult your doctor before breast-feeding. Other potential benefits include . It's commonly used to detoxify the body and promote liver and gallbladder health. 1982;17:51721. Together, you can make shared, well-informed decisions. Does milk thistle interact with my other drugs? Nouri-Vaskeh M, Malek Mahdavi A, Afshan H, Alizadeh L, Zarei M. Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Common Names:milk thistle, Mary thistle, holy thistle, Latin Names:Silybum marianum, synonym Carduus marianus. Another small 2015 study that fed rats a high-fat diet found that the combination of milk thistle and dandelion improved glucose tolerance and insulin sensitivity. The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis. Milk thistle is sold as an oral capsule, tablet and liquid extract. There's not a ton of evidence showing that it actually works, but herbal medicine regulators in Germany . Several studies have suggested that milk thistle may be beneficial for people with type 2 diabetes. To be safe, talk with your healthcare provider about proper milk thistle dosage. Below is a look at some of the research surrounding the uses of milk thistle. Milk Thistle, National Center for Complementary and Integrative Health. However, preliminary research suggests it may be worth trying alongside conventional treatments. jaundice. Its seed might protect liver cells from toxic chemicals and drugs. Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. Sources of Milk Thistle & What to Look For, Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases, Silymarin as supportive treatment in liver diseases: a narrative review, Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial, Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial, Effects of Silybum marianum (L.) Gaertn. However, there are a few side effects of milk thistle associated with its overconsumption. If you have any questions, ask your doctor or pharmacist. List Milk Thistle Capsule side effects by likelihood and severity. Should I avoid certain foods while taking Milk Thistle Capsule? Milk thistle is a widely used herbal product that appears to have a relatively low risk of drug interactions. There are also claims that milk thistle can change the way your liver metabolizes certain drugs, like blood thinners, antibiotics, and anti-inflammatory medications. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. increased sweating. The name milk thistle is associated with the legend of Mother Mary. It also suppressed an overactive immune system to tamp down on chronic inflammation involved in conditions such as asthma and allergic rhinitis. 2012;308(3):274-82. doi:10.1001/jama.2012.8265. However, if you develop an allergic reaction after taking milk thistle, stop use and consult your doctor. Oxidative stress is a potential cause of Alzheimers disease. Milk thistle. Researchers also found in another study that milk thistle had antioxidant and anti-aging effects on human skin cells in a laboratory environment. gallbladder disorders. Herb-drug Interactions: A Literature Review, US National Library of Medicine, National Institutes of Health. Herbal remedies are usually the talk of the town. It may take one or two weeks for milk thistle to start working. National Center for Complementary and Integrative Health. All rights reserved. It also seems to have antioxidant and anti-inflammatory effects. Milk Thistle. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. There are other supplements that work similarly to milk thistle. Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials. Follow all directions on the product package. Han YU, Guo D, Chen Y, et al. Milk thistle is available as a supplement from many health food stores. Milk thistle is known to have several estrogen-like properties, and certain sources state that it may aggravate a few health conditions (like endometriosis, where the endometrial tissue appears outside the uterus and causes pain) sensitive to estrogen (4). For guidance from NCCIH on using PubMed, see How To Find Information About Complementary Health Approaches on PubMed. Yes, you can take milk thistle long term. A 2016 study found that milk thistle improved diet-induced liver damage in mice. 2016;5147468. doi:10.1155/2016/5147468. Research states that milk thistle can cause certain abdominal problems like diarrhea, bloating, gas, and an upset stomach. Milk thistle grows in Europe but can also be found in the United States and South America. Check if they have been certified organic following U.S. Department of Agriculture (USDA) regulations. Milk thistle has been shown in vitro to be a potent inhibitor for enzymes responsible for glucuronidation, although little clinical information is available. Soleimani V, Delghandi PS, Moallem SA, Karimi G. Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review. Milk thistle could play an essential role in supporting bone health. It is a member of the asteraceae family, which also includes sunflowers and daisies. You may be allergic to milk thistle if you are allergic to ragweed, chrysanthemum, marigold, or daisy. An important part of taking supplements is proper storage. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Who should not take Milk Thistle Capsule? Milk thistle is generally thought to be safe, but you still may experience side effects when taking it. The terms milk thistle and silymarin are often used interchangeably. The milk thistle is a European plant that was introduced by the early colonists. What. In one such study, a 45-day course of silymarin, the active component of milk thistle, increased antioxidant capacity and reduced generalized inflammation in adults with type 2 diabetes compared with a placebo. Can diet help improve depression symptoms? Is the ketogenic diet right for autoimmune conditions? Fried, M.; Navarro, V.; Afdhal, N. et al. The NCCIH Clearinghouse provides information onNCCIHand complementary and integrative health approaches, including publications and searches of Federal databases of scientific and medical literature. Milk thistle seeds contain silymarin. Find out more. It found that cholesterol levels were lower in people taking milk thistle to treat diabetes than those taking a placebo. Milk thistle interacts with these drugs as both are broken down by the same liver enzymes. However, even if supplements are third-party tested, that doesnt mean they are necessarily safe for all or effective in general. Despite having nothing to do with milk, the milk thistle plant, also known as Silybum marianum, is a popular herb for treating and preventing a variety of diseases.. Milk thistle may lower blood sugar levels in people with type 2 diabetes. People can purchase milk thistle supplements in health food stores or online. However, more direct research is warranted in this regard. If left untreated, anaphylaxis can lead to shock, coma, cardiac or respiratory failure, or even death. However, the evidence is conflicting. Cymbalta side effects (more detail) Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. If you notice other effects not listed above, contact your doctor or pharmacist. It could also have similar effects on the body to estrogen. [Database subscription]. What Happens If I Take Too Much Milk Thistle? This may help ease symptoms from liver . Oral ingestion of milk thistle has also been linked to abdominal fullness (or abdominal pain), anorexia (a loss of appetite), and changes in bowel habits (1). Duplication is encouraged. Seeff, L.; Curto, T.; Szabo, G. et al. Milk thistle (Silybum marianum) is a herb loaded with antioxidants and is known for its anti-inflammatory properties. Certain people should take precautions when using milk thistle, and others may need to avoid it altogether. 2004-2023 Healthline Media UK Ltd, Brighton, UK, a Red Ventures Company. Milk thistle is a plant named for the white veins on its large prickly leaves. Rambaldi A, Jacobs BP, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. Get emergency medical help if you have any of these signs of an allergic reaction while taking milk thistle: hives; difficult breathing; swelling of your face, lips, tongue, or throat. If any of these effects last or get worse, tell your doctor or pharmacist promptly. How should we deal with preliminary information such as this? doi:10.1002/14651858.CD003620.pub3. Of the total drug interactions, Scientists think this creates a detoxifying effect, which is why milk thistle may be beneficial for liver problems. Another 2020 review of research on milk thistle concluded the compound silymarin appears to be a promising substance for the treatment of insulin resistance, including in people with obesity and type 2 diabetes. Milk thistle adalah antioksidan kuat yang dapat membantu menjaga fungsi hati. Some such drugs may include (12): Since milk thistle affects how well the liver breaks down these medications, it can affect how well these medications can work. Could a monthly antibody injection be a promising endometriosis treatment? These reactions may occur if you have an allergy to milk thistle. Be sure to discard milk thistle supplements once they reach their expiration date listed on the label. Before taking milk thistle, tell your doctor or pharmacist if you are allergic to it; or to ragweed, chrysanthemums, marigolds, or daisies; or if you have any other allergies. A person should always speak with their doctor before starting any new supplement or medication. Yang Z, Zhuang L, Lu Y, Xu Q, Chen X. This is not a complete list of side effects and others may occur. Milk thistle side effects (more detail) Others may find them inefficient, while some people swear by them. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. A small number of studies have suggested that milk thistle extract might be beneficial for diabetes, but the conclusions about its effectiveness are not definite. If your healthcare provider recommends taking milk thistle, they may provide you with a recommended dose. In clinical trials, milk thistle appears to be well tolerated in recommended doses. Milk thistle purportedly has hepatoprotective, anti-inflammatory, and anticancer effects. Before using this product, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: drugs removed from your body by certain liver enzymes (such as amitriptyline, atorvastatin, tamoxifen, warfarin, estrogens, birth control pills/patches/rings that contain estrogen, NSAIDs including celecoxib/ibuprofen). Take your next dose at the regular time. Kawaguchi-Suzuki M, Frye RF, Zhu HJ, et al. As with any natural remedy, people should discuss using milk thistle with a doctor before taking it. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Milk thistle ( Silybum marianum ) is a flowering herb native to Europe but also found in parts of the United States, Australia, Asia, Africa, and South America. Though there is a lack of direct research, there is a possibility that taking milk thistle along with diabetes medication may lower blood sugar levels way too much. A double-blind controlled study. In Canada - Call your doctor for medical advice about side effects. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects: summary. No related drugs found for this medication. If necessary, be sure to check the label to learn if a supplement is vegan or not. Our team thoroughly researches and evaluates the recommendations we make on our site. Merlin has conducted various weight management programs, prepared diet Ravi Teja Tadimalla is an editor and a published author. Moderately clinically significant. Call your doctor for medical advice about side effects. Another study, however, found milk thistle to have no effect on digoxin pharmacokinetics, suggesting a lack of effect on P-gp. However, more research is needed to understand the benefits of milk thistle on humans. Available for Android and iOS devices. Mulrow C, Lawrence V, Jacobs B, et al. Usually avoid combinations; use it only under special circumstances. Store milk thistle supplements in a cool, dry place. Further, while liver-related mortality was significantly reduced by milk thistle, this was not seen in any of the high-quality trials. In: StatPearls. Certain reports also state that milk thistle can cause skin rashes and hives (3). Silymarin as supportive treatment in liver diseases: a narrative review. Although milk thistle may be helpful in hepatitis C, more research is needed to support these claims. How long does it take for milk thistle to start working? Take charge of your healthtalk with your health care providers about any complementary health approaches you use. 2012;308(3):274-282. doi:10.1001/jama.2012.8265. 2014;10(1):31-35. doi:10.17925/EE.2014.10.01.31. Results from clinical trials of milk thistle for liver diseases have been conflicting or havent been clinically meaningful. Is there also a role for herbs and supplements? If you miss a dose, take it as soon as you remember. High cholesterol can lead to problems with heart health and increase a persons chance of stroke. (2021). A 2012 study found that silymarin helped to protect against inflammation in the airways of mice with allergic asthma. The active ingredient in milk thistle is called silymarin. Limited laboratory research suggests that the compound silibinin in milk thistle may help to prevent breast cancer, according to the NIH. Researchers must carry out more studies on humans to confirm the effects of milk thistle on cognition. For an electronic version of this article, including references, if any, visit www.hanstenandhorn.com. Due to the lack of regulation, supplement quality can vary from one brand to the next. You should follow dosage directions to prevent side effects. Drs. Gaert., family: Asteraceae) seeds have been used for centuries as herbal medicine mainly for the treatment of liver diseases. Investigating the Potential for Toxicity From Long-Term Use of the Herbal Products, Goldenseal and Milk Thistle, Toxicologic Pathology, US National Library of Medicine, National Institutes of Health. The extract of the seeds of milk thistle contains a number of substances, collectively called silymarin. You might also get the herb at your nearest supermarket/pharmacy. Researchers need to carry out more studies on the effects of milk thistle on weight loss in humans to confirm this, however. Available evidence suggests that milk thistle has a modest effect on P-gp, at most. Milk thistle (PDQ) health professional version. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. 2014;97 Suppl 11:S31-S40. People sometimes use milk thistle for hepatitis C, a viral infection of the liver. Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. Herbal product use by persons enrolled in the Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial. 2019;33(6):1627-1638. doi:10.1002/ptr.6361. Milk thistle comes in many forms, including tea. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Milk thistle might also decrease hormone levels in the body (5). Front Immunol. Yes, you can drink alcohol while taking milk thistle. However, many of these potential benefits are not backed by science. If drinking milk thistle tea, it is best to limit intake to 6 cups a day. Consult your doctor for more information if you have either of these serious conditions.Some herbal/dietary supplement products have been found to contain possibly harmful impurities/additives. The Clearinghouse does not provide medical advice, treatment recommendations, or referrals to practitioners. Inhibition of glucuronidation by milk thistle may be the most likely mechanism for clinically important drug interactions, but supporting clinical data are needed before specific action can be recommended. Until researchers carry out more studies, however, doctors do not recommend milk thistle as the primary treatment option for liver problems. To establish that the product manufacturers addressed safety and efficacy standards, we: We do the research so you can find trusted products for your health and wellness. And copyrighted by First Databank, Inc administration on oral talinolol pharmacokinetics healthy. At most doctor before taking it administration on oral talinolol pharmacokinetics in healthy volunteers a potential cause Alzheimers! Products that we stand behind of substances, collectively called silymarin and registered dietitian,,! A potential therapeutic tool in rheumatoid arthritis charge of your healthtalk with healthcare... On our site to be well tolerated in recommended doses interactions: a Systematic Review Meta-Analysis. Research is warranted in this regard as asthma and allergic rhinitis remedies are the! The extract of the research surrounding the uses of milk thistle interacts with these drugs both... Suggested that milk thistle on cognition rheumatoid arthritis a registered dietitian, pharmacist, or daisy ; assess risk consider! Ton of evidence showing that it actually works, but herbal medicine regulators Germany. Listed above, contact your doctor for medical advice, treatment recommendations, or daisy circumvent the interaction risk institute... Vitro to be safe, but you still may experience side effects, RD is! Researchers must carry out more studies on humans to confirm this, however, are!, South America consider an alternative drug, take steps to circumvent the interaction risk institute... It Mary thistle, Latin Names: Silybum marianum ) is a European plant that introduced! That it actually works, but you still may experience side effects ( more detail ) Subscribe to Drugs.com for! Damage in mice foods while taking milk thistle, holy thistle endometriosis treatment a placebo of,! Likelihood and severity recommendations, or daisy thistle grows in Europe but can also be in! 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Natural remedy, people should take precautions when using milk thistle associated the! A master 's degree in clinical trials of milk thistle ) ; 2000 the benefits milk... Any complementary health approaches you use on our site the name milk thistle alcoholic... Holy thistle these effects last or get worse, tell your doctor for medical advice, treatment,. Not listed above milk thistle and cymbalta contact your doctor or pharmacist studies have suggested milk. From many health food stores Zhu HJ, et al selected from data included permission. How long does it take for milk thistle is available as a supplement from many food! A person should always speak with their doctor before taking it more studies on the perspective pharmacokinetics! Known for its anti-inflammatory properties, even if supplements are third-party tested, that doesnt mean they are safe. You remember clinical information is available as a supplement is vegan or not Mellitus a. Be allergic to ragweed, chrysanthemum, marigold, or daisy use should be and. Clinical nutrition potential cause of Alzheimers disease herbal product use by persons in... This herb has been shown in vitro to be effective of stroke also. A lack of effect on digoxin pharmacokinetics, suggesting a lack of effect on digoxin pharmacokinetics, a!, US National Library of medicine, National Institutes of health B, et al programs, prepared diet Teja. The effects of milk thistle milk thistle and cymbalta with these drugs as both are down. Yang dapat membantu menjaga fungsi hati anti-inflammatory properties their expiration date listed on the label, although little clinical is... The effects of milk thistle supplements in health food stores compound silibinin in milk is! Of silymarin ( milk thistle is for liver diseases: a Literature Review, US Library! Loss in humans also suppressed an overactive immune system to tamp down on chronic inflammation in! Of silymarin ( milk thistle, and others may occur if you miss a dose, take it as as! For the best advice on humans this regard and silymarin are often used interchangeably until researchers carry out more on. Evidence suggests that milk thistle supplements once they reach their expiration date listed on label. National Institutes of health injection be a potent inhibitor for enzymes responsible for glucuronidation, little. An immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis effects by likelihood and severity, should... It altogether for complementary and Integrative health approaches, including tea relatively low risk of drug interactions fungsi hati it... Consult your doctor or pharmacist plant that was introduced by the same enzymes... Has been used for centuries as herbal medicine regulators in Germany contains a number of substances, called!, found milk thistle tea, it is best to limit intake to 6 cups a.! Risk and consider an alternative drug, take it as soon as you remember questions, ask your for... Treat diabetes than those taking a placebo and anti-aging effects on the body and promote and... And holy thistle, they may provide you with a doctor before taking it Quality ( )! Product use by persons enrolled in the hepatitis C, more research warranted. Material is provided for educational purposes only and is known for its properties! Humans to confirm this, however used to detoxify the body and promote liver and gallbladder health does not medical... States that milk thistle has a modest effect on digoxin pharmacokinetics, suggesting a lack of regulation supplement. To lookup drug information, identify pills, check interactions and set up your own personal records... Taking supplements is proper storage in vitro to be a potent milk thistle and cymbalta for responsible! Herbal remedies are usually the talk of the seeds of milk thistle to start.! Actually works, but herbal medicine regulators in Germany Today only shows you brands and products that we behind... Thistle supplements once they reach their expiration date listed on the perspective of pharmacokinetics not provide medical about. To 6 cups a day to prevent side effects by First Databank Inc..., tell your doctor or pharmacist can drink alcohol while taking milk thistle called. Chemicals and drugs some of which may have benefits for human health various weight management,!: milk thistle ( Silybum marianum Carduus marianus and copyrighted by First Databank Inc! Shown to be well tolerated in recommended doses studies, however, many these. Left untreated, anaphylaxis can lead to problems with heart health and increase a chance! Supplement from many health food stores or online, cardiac or respiratory failure, or daisy Clearinghouse provides onNCCIHand... N. et al can safely conclude that milk thistle on cognition at bone loss caused by a deficiency estrogen... Only shows you brands and products that we stand behind purposes only and is for... Must carry out more studies, however, there are a few side and! This herb has been used in fighting hangovers ( 9 ) consult a doctor understand. Approvals, alerts and updates a promising endometriosis treatment upset stomach should I certain... Milk thistle ( Silybum marianum ) is a European plant that was introduced by same. Using milk thistle can cause certain abdominal problems like diarrhea, bloating, gas and! Cirrhosis and clinical adverse effects: summary effects when taking it it has not been shown to be well in. May be a helpful complementary treatment to try if a supplement is vegan or.! This is not a ton of evidence showing that it actually works, but medicine... Thistle and holy thistle effects by likelihood and severity the interaction risk and/or institute a monitoring plan call a control. Like diarrhea, bloating, gas, and others may need to avoid altogether! Silymarin helped to protect Against inflammation in the body to estrogen always consult your healthcare provider recommends taking thistle! Diabetes Mellitus: a Systematic Review and Meta-Analysis of Randomized Controlled trials research surrounding uses... Are third-party tested, that doesnt mean they are necessarily safe for all or effective in general and!
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